Medline Plus Medical Encyclopedia: Spindle Cell Melanoma

Friday, August 31, 2018

Spindle Cell Melanoma

Incidence and survival 1973 to 2017. The exact cause of spindle cell melanoma is unknown.

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The aim of the present study was to investigate the incidence of SCM its general demographics basic clinico-pathologic features treatment outcomes and.

Spindle cell melanoma. However other subtypes are much rarer 5. It is a very aggressive form of cancer and patients who are diagnosed generally do not live more than five years. The diagnosis of SCM is challenging as SCM may occur anywhere on the body and frequently mimics amelanotic lesions including scarring and inflammation 24.

On microscopy it is often mistaken for other skin and soft tissue cancers with spindle cell morphologies. A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. The generic term spindle cell melanoma refers to a malignant melanocytic lesion with a uniform spindle cell cytomorphology.

At one end of the spectrum is the typical paucicellular scar-like variant. Early detection is uncommon. The characteristic spindle cell phenotype of the neoplastic cells in SpCC is the result of epithelial-mesenchymal transition.

Spindle cell melanoma refers to invasive melanomas in which the tumor is predominantly or exclusively composed of spindle cells. The lesions are usually found on the head and neck region and present as bulky firm fibrous masses of tumour or indurated plaquesThese are usually amelanotic lesions. Melanomas occurring on the extremities of blacks tend to be of the acral lentiginous type.

Spindle cell melanoma is a rare subtype of melanoma which is relatively uncharacterized but most commonly occurs in caucasian people of 6080 years of age with a predominance in males. Spindle cell melanoma. Some tumors with scattered spindle cells and abundant collagen.

Hence these are vulnerable to be misinterpreted as other neoplasms. Desmoplastic melanoma versus spindle cell melanoma. Spindle cell melanoma constitutes a relatively uncommon variant of melanoma characterized by tumor cells with distinctly spindled morphology.

Epithelioid and spindle cells. Forums General Melanoma Community Spindle Cell This topic has 9 replies 3 voices and was last updated 4 years 3 months ago by tag4128. At the other end is a high grade sarcoma-like pleomorphic spindle cell melanoma with only partial desmoplasia Adv Anat Pathol 20051292 May be pure or mixed associated with conventional melanoma Pure.

In many cases such lesions are in fact nodular melanomas with complete spindled morphology. It is a fibrosing variant of spindle cell melanoma. Xu Z Yibulayin F Shi P Feng L Medicine Baltimore 2018 Jul9729e11563.

Spindle cell melanoma is a morphological variant which can be readily misinterpreted due to a lack of classical cytological features of melanoma. They most commonly arise in superficial spreading and nodular melanomas. Others with high cellularity and little stroma best classified as spindle cell melanoma Small foci of lymphoid aggregates is a useful clue to the diagnosis on scanning.

Spindle cell melanoma SCM is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles. May be pure or combined with classic melanoma. Melanoma cells can be categorized in two major types.

Representative example is the type A spindle cell uveal melanoma. Spindle cell carcinoma is a type of cancer which usually originates in the connective tissues of the body. Spindle cell melanoma is a rare histological variant of melanoma characterised by the presence of spindle-shaped melanocytes 1.

In contrast to AFX PDS is an ill-defined infiltrative malignant neoplasm that invades deep subcutaneous tissue and shows tumor necrosis and lymphovascular invasion with local recurrence in 28 and metastasis in 10. Spindle cell carcinoma SpCC also referred to as sarcomatoid carcinoma is a biphasic tumor composed of conventional SCC and malignant spindle cells. 90 or more desmoplastic type.

Desmoplastic melanoma Desmoplastic melanoma. Spindle cell melanoma is positive for S100 protein whereas AFX is entirely negative. When cells from this type of cancer are viewed under a microscope they appear spindle-shaped.

This represents etiologically and genetically a diverse group of melanomas. Epithelioid cells are large and round with abundant eosinophilic cytoplasm prominent vesicular nuclei and large nucleoli. Spindle cell melanoma SCM is a rare morphological subtype of melanoma which is relatively uncharacterized.

An awareness of clinical and cytological features is important to reach the correct d. Spindle cell features may be seen in the invasive component of various melanomas lentigo maligna acral superficial spreading nodular.

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